Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.9
USERS' SCORE
Good
Based on 54 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Selenium (elemental) (from 20 mg L-Selenomethionine)
100 mcg
182%
Top Medical Research Studies
9
Selenium aids Graves' orbitopathy treatment
We explored how selenium supplementation might help individuals suffering from Graves' orbitopathy, an autoimmune disorder linked to thyroid dysfunction. Our approach involved a systematic review and meta-analysis that assessed results from four randomized controlled trials.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
Read More
0
We aimed to explore how selenium affects autoimmune thyroid disease (AITD), specifically looking at three conditions: autoimmune thyroiditis (AIT), autoimmune hyperthyroidism (AIH), and Graves' disease (GD). Using a research method called Mendelian randomization, we analyzed genetic data to establish potential causal links between selenium levels and these autoimmune disorders.
Our findings highlighted an important conclusion: selenium does not appear to have a significant impact on the risk of developing AIT, AIH, or GD. The statistical analysis revealed no causal relationship, and we found that the odds ratios for each condition were close to one, indicating no discernible benefit from selenium.
Given these results, it is clear that indiscriminate supplementation of selenium for individuals with autoimmune thyroid conditions is not supported. Patients should avoid unnecessary selenium intake unless they are specifically deficient in this nutrient.
Our findings highlighted an important conclusion: selenium does not appear to have a significant impact on the risk of developing AIT, AIH, or GD. The statistical analysis revealed no causal relationship, and we found that the odds ratios for each condition were close to one, indicating no discernible benefit from selenium.
Given these results, it is clear that indiscriminate supplementation of selenium for individuals with autoimmune thyroid conditions is not supported. Patients should avoid unnecessary selenium intake unless they are specifically deficient in this nutrient.
Read More
9
We explored the effects of selenium supplements on patients with Hashimoto's thyroiditis, an autoimmune disorder that can affect thyroid function. Through a structured analysis of studies, we focused on how selenium could potentially lower the levels of thyroid autoantibodies.
Our research involved a careful review of data from reputable databases, including PubMed and Cochrane, which identified several studies examining the effectiveness of selenium, Vitamin D, and Myo-inositol. Among these, the results showed that selenium supplementation significantly reduced both thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb) when compared to a placebo group.
Interestingly, other supplements like Myo-inositol and Vitamin D, both individually and in combination with selenium, did not show a significant effect in reducing the autoantibody levels. Based on these findings, it appears that incorporating selenium into treatment regimens may offer a beneficial adjunct for those managing Hashimoto's thyroiditis.
Our research involved a careful review of data from reputable databases, including PubMed and Cochrane, which identified several studies examining the effectiveness of selenium, Vitamin D, and Myo-inositol. Among these, the results showed that selenium supplementation significantly reduced both thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb) when compared to a placebo group.
Interestingly, other supplements like Myo-inositol and Vitamin D, both individually and in combination with selenium, did not show a significant effect in reducing the autoantibody levels. Based on these findings, it appears that incorporating selenium into treatment regimens may offer a beneficial adjunct for those managing Hashimoto's thyroiditis.
Read More
Most Useful Reviews
9
Significant hair recovery
409 people found this helpful
After suffering from covid, my wife was told by a doctor that her hair was beyond saving. After researching and trying various treatments, I decided to give her selenium in a 100mcg capsule, three times a day. Within a month, she noticed significant improvements - her dry, itchy scalp cleared up, and new hair began growing, bringing back her confidence and lifting her mood. I strongly recommend selenium to anyone facing similar issues; it genuinely worked wonders for us.
Read More
9
Improved sperm quality
266 people found this helpful
We purchased selenium to enhance my husband’s sperm quality as we are trying for a baby. Selenium significantly boosted sperm motility and maturation. After a month, we saw remarkable improvements, leading to a positive pregnancy test. For those facing similar situations, I recommend combining it with zinc and vitamin E for better results.
Read More
9
Excellent mineral treatment
20 people found this helpful
GOOD MINERAL! THE RESULT IS CONFIRMED BY ANALYSIS! TAKEN ON THE RECOMMENDATION OF THE ENDOCRINOLOGIST! AFTER THREE MONTHS, MY RESULTS ARE MUCH BETTER AND FUNDED THROUGH ANALYSIS. WE HAVE SUCH MINERAL AT A COST OF ABOUT £4,000 FOR THREE MONTHS, WHILE THIS ONE ONLY COST £400 – A SIGNIFICANT DIFFERENCE! VERY RECOMMENDED - AN EXCELLENT MINERAL!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.9
- All Researches
9
We explored the effects of selenium supplements on patients with Hashimoto's thyroiditis, an autoimmune disorder that can affect thyroid function. Through a structured analysis of studies, we focused on how selenium could potentially lower the levels of thyroid autoantibodies.
Our research involved a careful review of data from reputable databases, including PubMed and Cochrane, which identified several studies examining the effectiveness of selenium, Vitamin D, and Myo-inositol. Among these, the results showed that selenium supplementation significantly reduced both thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb) when compared to a placebo group.
Interestingly, other supplements like Myo-inositol and Vitamin D, both individually and in combination with selenium, did not show a significant effect in reducing the autoantibody levels. Based on these findings, it appears that incorporating selenium into treatment regimens may offer a beneficial adjunct for those managing Hashimoto's thyroiditis.
Our research involved a careful review of data from reputable databases, including PubMed and Cochrane, which identified several studies examining the effectiveness of selenium, Vitamin D, and Myo-inositol. Among these, the results showed that selenium supplementation significantly reduced both thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb) when compared to a placebo group.
Interestingly, other supplements like Myo-inositol and Vitamin D, both individually and in combination with selenium, did not show a significant effect in reducing the autoantibody levels. Based on these findings, it appears that incorporating selenium into treatment regimens may offer a beneficial adjunct for those managing Hashimoto's thyroiditis.
Read More
9
Selenium aids Graves' orbitopathy treatment
We explored how selenium supplementation might help individuals suffering from Graves' orbitopathy, an autoimmune disorder linked to thyroid dysfunction. Our approach involved a systematic review and meta-analysis that assessed results from four randomized controlled trials.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
Read More
9
The study we looked into focused on selenium's impact on autoimmune thyroiditis, particularly Hashimoto's thyroiditis. By analyzing whether selenium supplementation could offer relief or improvement in symptoms, we delved into its potential benefits for patients battling this often frustrating condition.
Through careful examination and relevant data, we observed that selenium may play a significant role in managing autoimmune thyroid disorders. Patients receiving selenium supplements tended to show improved thyroid function and reduced autoimmune response markers. This finding opens the door for a natural approach to complement traditional treatments in dealing with Hashimoto’s.
Overall, we found evidence supporting the use of selenium as a valuable addition to the treatment regimen for patients with autoimmune thyroiditis. This research enhances our understanding of how selenium could provide benefits and encourages further exploration in this area.
Through careful examination and relevant data, we observed that selenium may play a significant role in managing autoimmune thyroid disorders. Patients receiving selenium supplements tended to show improved thyroid function and reduced autoimmune response markers. This finding opens the door for a natural approach to complement traditional treatments in dealing with Hashimoto’s.
Overall, we found evidence supporting the use of selenium as a valuable addition to the treatment regimen for patients with autoimmune thyroiditis. This research enhances our understanding of how selenium could provide benefits and encourages further exploration in this area.
Read More
8
We observed that selenium, an essential micronutrient, significantly impacts thyroid health, especially in the context of autoimmune disorders. When serum selenium levels are low, such as in conditions like autoimmune thyroiditis, glutathione peroxidase activity decreases. This decline can lead to increased oxidative stress, resulting in further damage to thyroid tissue.
Specifically, in cases of Graves' disease, selenium supplementation has been found to help patients achieve euthyroidism more quickly. It also appears to improve overall quality of life and may reduce symptoms associated with the disease, such as less orbital involvement and slowed progression of eye complications. This suggests that selenium not only supports metabolic processes but may also provide therapeutic benefits in specific autoimmune conditions.
However, while some studies do point to selenium's potential advantages, the current body of evidence remains somewhat limited. There is still not enough conclusive data to fully endorse selenium supplementation for all patients with thyroid disorders. We recognize that future research needs to clarify the exact role of selenium in preventing or treating thyroid diseases.
Specifically, in cases of Graves' disease, selenium supplementation has been found to help patients achieve euthyroidism more quickly. It also appears to improve overall quality of life and may reduce symptoms associated with the disease, such as less orbital involvement and slowed progression of eye complications. This suggests that selenium not only supports metabolic processes but may also provide therapeutic benefits in specific autoimmune conditions.
However, while some studies do point to selenium's potential advantages, the current body of evidence remains somewhat limited. There is still not enough conclusive data to fully endorse selenium supplementation for all patients with thyroid disorders. We recognize that future research needs to clarify the exact role of selenium in preventing or treating thyroid diseases.
Read More
8
We explored the effects of selenium treatment on immune dysregulation in lupus, a common autoimmune disorder. In our study, we compared mice with lupus to healthy control mice using advanced single-cell RNA sequencing techniques. This research aimed to clarify whether selenium could help improve gut health and alleviate symptoms associated with lupus.
Our findings revealed a significant decrease in specific immune cells known as CD8αα + intraepithelial lymphocytes (IELs) in the lupus mice. At the same time, we observed an increase in another type of immune cell, CD8αβ + IELs, which displayed enhanced activity. Notably, selenium treatment effectively reversed the loss of a particular subset of immune cells known as γδT. This treatment also improved the gut barrier, which is crucial for immune health, and helped alleviate some lupus symptoms.
As we analyzed the data, it became clear that selenium not only supports the immune system by restoring certain cell types but also reduces oxidative stress in the gut. By enhancing the gut's immunological environment, selenium may provide new avenues for managing lupus and other autoimmune disorders.
Our findings revealed a significant decrease in specific immune cells known as CD8αα + intraepithelial lymphocytes (IELs) in the lupus mice. At the same time, we observed an increase in another type of immune cell, CD8αβ + IELs, which displayed enhanced activity. Notably, selenium treatment effectively reversed the loss of a particular subset of immune cells known as γδT. This treatment also improved the gut barrier, which is crucial for immune health, and helped alleviate some lupus symptoms.
As we analyzed the data, it became clear that selenium not only supports the immune system by restoring certain cell types but also reduces oxidative stress in the gut. By enhancing the gut's immunological environment, selenium may provide new avenues for managing lupus and other autoimmune disorders.
Read More
User Reviews
USERS' SCORE
Good
Based on 54 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant hair recovery
409 people found this helpful
After suffering from covid, my wife was told by a doctor that her hair was beyond saving. After researching and trying various treatments, I decided to give her selenium in a 100mcg capsule, three times a day. Within a month, she noticed significant improvements - her dry, itchy scalp cleared up, and new hair began growing, bringing back her confidence and lifting her mood. I strongly recommend selenium to anyone facing similar issues; it genuinely worked wonders for us.
Read More
9
Improved sperm quality
266 people found this helpful
We purchased selenium to enhance my husband’s sperm quality as we are trying for a baby. Selenium significantly boosted sperm motility and maturation. After a month, we saw remarkable improvements, leading to a positive pregnancy test. For those facing similar situations, I recommend combining it with zinc and vitamin E for better results.
Read More
9
Excellent mineral treatment
20 people found this helpful
GOOD MINERAL! THE RESULT IS CONFIRMED BY ANALYSIS! TAKEN ON THE RECOMMENDATION OF THE ENDOCRINOLOGIST! AFTER THREE MONTHS, MY RESULTS ARE MUCH BETTER AND FUNDED THROUGH ANALYSIS. WE HAVE SUCH MINERAL AT A COST OF ABOUT £4,000 FOR THREE MONTHS, WHILE THIS ONE ONLY COST £400 – A SIGNIFICANT DIFFERENCE! VERY RECOMMENDED - AN EXCELLENT MINERAL!
Read More
7.5
Energy Increase
13 people found this helpful
I'm pleased with my purchase! Selenium supports the endocrine, immune, and reproductive systems. It protects against free radicals and promotes normal cell growth. After just a week, my strength, mood, and overall condition improved tremendously, especially with my thyroid issues. Highly recommend!
Read More
9
Doctor Recommended
7 people found this helpful
Great selenium! I have thyroid problems, and my doctor recommended it for consistent use. I have switched to this particular form, which is well absorbed. It suits me financially, and my tests show it’s effective. I recommend it as well.
Read More
Frequently Asked Questions
6
Reduced hair loss
21 people found this helpful
It was surprisingly effective. I have metal allergies, a stiff neck, thyroid issues, and blisters on my feet, which prompted my order. By the third day of use, I noticed a significant reduction in hair loss while shampooing! This unexpected change has delighted me. My current supplements include Candida Support and NAC in the morning for detox, and MSM, Silica, and Vitamin C in the afternoon.
7.5
Energy Increase
13 people found this helpful
I'm pleased with my purchase! Selenium supports the endocrine, immune, and reproductive systems. It protects against free radicals and promotes normal cell growth. After just a week, my strength, mood, and overall condition improved tremendously, especially with my thyroid issues. Highly recommend!
9
Effective treatment
1 people found this helpful
This isn’t my first purchase; my endocrinologist prescribed a three-month course for my autoimmune thyroiditis. I monitor my progress through blood tests—hormones are normalising! I used to take Solgar, but this one is cheaper and shows no difference.
9
Thyroid support
1 people found this helpful
Prescribed by a doctor for autoimmune thyroiditis, my TTG, TE, and T3 levels have returned to normal. The function of my thyroid gland has improved, and my antibodies have decreased. It is a perfect supplement with a safe composition.
9
Improved sperm quality
266 people found this helpful
We purchased selenium to enhance my husband’s sperm quality as we are trying for a baby. Selenium significantly boosted sperm motility and maturation. After a month, we saw remarkable improvements, leading to a positive pregnancy test. For those facing similar situations, I recommend combining it with zinc and vitamin E for better results.
7.5
Very helpful for condition
1 people found this helpful
I have been dealing with an autoimmune disorder, and my doctor prescribed selenium. I took 200 mg for the first two weeks, then reduced to 100mg, which has helped me tremendously. It's essential to consult with a health carer, as large doses and prolonged use may be toxic.
9
Increased wellbeing
1 people found this helpful
Excellent! Since starting selenium along with kelp, vitamin D, and vitamin C, I’ve felt better despite living with Hashimoto's autoimmune disease. I trust the NOW brand as their products are free from allergens or pesticides, and they come at a reasonable price.
9
Improved thyroid function
5 people found this helpful
Selenium is essential for thyroid health! By replenishing selenium reserves first, we can then introduce iodine. Selenium effectively lowers TSH and antibodies, as indicated in studies. This product caused no allergies or adverse effects and is well-tolerated. I advise considering natural sources of selenium as well!
7.5
Supports thyroid function
25 people found this helpful
Great product. I recommend selenium to keep the thyroid functioning well. I take it with kelp and suggest this manufacturer for its excellent value for money.
9
Reduced hair loss
3 people found this helpful
I consume selenium twice a year for two weeks on my endocrinologist's advice, having autoimmune thyroiditis. The suitable dosage for me is 100 mg. I've noticed that within a few days of taking selenium, my hair loss dramatically reduces; the comb comes away clean. This is a consistent outcome every time I take it. I hope this feedback is useful to you.
7.5
Effective treatment
9 people found this helpful
Selenium is effective but should not be taken long-term unchecked, as excess can be more dangerous than a deficiency. It has good digestibility and no side effects for me. Just remember to take it in cycles, monitoring selenium levels, as I experienced elevated levels after two months for my autoimmune thyroiditis.
7.5
Recommended for AIT
4 people found this helpful
My endocrinologist recommended Selenium to manage my AIT - Autoimmune thyroiditis. I advocate its use for thyroid health and overall immune support.
9
We explored the effects of selenium supplements on patients with Hashimoto's thyroiditis, an autoimmune disorder that can affect thyroid function. Through a structured analysis of studies, we focused on how selenium could potentially lower the levels of thyroid autoantibodies.
Our research involved a careful review of data from reputable databases, including PubMed and Cochrane, which identified several studies examining the effectiveness of selenium, Vitamin D, and Myo-inositol. Among these, the results showed that selenium supplementation significantly reduced both thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb) when compared to a placebo group.
Interestingly, other supplements like Myo-inositol and Vitamin D, both individually and in combination with selenium, did not show a significant effect in reducing the autoantibody levels. Based on these findings, it appears that incorporating selenium into treatment regimens may offer a beneficial adjunct for those managing Hashimoto's thyroiditis.
Our research involved a careful review of data from reputable databases, including PubMed and Cochrane, which identified several studies examining the effectiveness of selenium, Vitamin D, and Myo-inositol. Among these, the results showed that selenium supplementation significantly reduced both thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb) when compared to a placebo group.
Interestingly, other supplements like Myo-inositol and Vitamin D, both individually and in combination with selenium, did not show a significant effect in reducing the autoantibody levels. Based on these findings, it appears that incorporating selenium into treatment regimens may offer a beneficial adjunct for those managing Hashimoto's thyroiditis.
9
Selenium aids Graves' orbitopathy treatment
We explored how selenium supplementation might help individuals suffering from Graves' orbitopathy, an autoimmune disorder linked to thyroid dysfunction. Our approach involved a systematic review and meta-analysis that assessed results from four randomized controlled trials.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
8
We explored the effects of selenium treatment on immune dysregulation in lupus, a common autoimmune disorder. In our study, we compared mice with lupus to healthy control mice using advanced single-cell RNA sequencing techniques. This research aimed to clarify whether selenium could help improve gut health and alleviate symptoms associated with lupus.
Our findings revealed a significant decrease in specific immune cells known as CD8αα + intraepithelial lymphocytes (IELs) in the lupus mice. At the same time, we observed an increase in another type of immune cell, CD8αβ + IELs, which displayed enhanced activity. Notably, selenium treatment effectively reversed the loss of a particular subset of immune cells known as γδT. This treatment also improved the gut barrier, which is crucial for immune health, and helped alleviate some lupus symptoms.
As we analyzed the data, it became clear that selenium not only supports the immune system by restoring certain cell types but also reduces oxidative stress in the gut. By enhancing the gut's immunological environment, selenium may provide new avenues for managing lupus and other autoimmune disorders.
Our findings revealed a significant decrease in specific immune cells known as CD8αα + intraepithelial lymphocytes (IELs) in the lupus mice. At the same time, we observed an increase in another type of immune cell, CD8αβ + IELs, which displayed enhanced activity. Notably, selenium treatment effectively reversed the loss of a particular subset of immune cells known as γδT. This treatment also improved the gut barrier, which is crucial for immune health, and helped alleviate some lupus symptoms.
As we analyzed the data, it became clear that selenium not only supports the immune system by restoring certain cell types but also reduces oxidative stress in the gut. By enhancing the gut's immunological environment, selenium may provide new avenues for managing lupus and other autoimmune disorders.
0
We aimed to explore how selenium affects autoimmune thyroid disease (AITD), specifically looking at three conditions: autoimmune thyroiditis (AIT), autoimmune hyperthyroidism (AIH), and Graves' disease (GD). Using a research method called Mendelian randomization, we analyzed genetic data to establish potential causal links between selenium levels and these autoimmune disorders.
Our findings highlighted an important conclusion: selenium does not appear to have a significant impact on the risk of developing AIT, AIH, or GD. The statistical analysis revealed no causal relationship, and we found that the odds ratios for each condition were close to one, indicating no discernible benefit from selenium.
Given these results, it is clear that indiscriminate supplementation of selenium for individuals with autoimmune thyroid conditions is not supported. Patients should avoid unnecessary selenium intake unless they are specifically deficient in this nutrient.
Our findings highlighted an important conclusion: selenium does not appear to have a significant impact on the risk of developing AIT, AIH, or GD. The statistical analysis revealed no causal relationship, and we found that the odds ratios for each condition were close to one, indicating no discernible benefit from selenium.
Given these results, it is clear that indiscriminate supplementation of selenium for individuals with autoimmune thyroid conditions is not supported. Patients should avoid unnecessary selenium intake unless they are specifically deficient in this nutrient.
References
- Souza LSL, Campos RO, Braga JS, Jesus JDS, Ramos HE, et al. Selenium nutritional status and thyroid dysfunction. Arch Endocrinol Metab. 2025;69:e230348. 10.20945/2359-4292-2023-0348
- Wang Q, Wu Y, Ouyang L, Min X, Zheng M, et al. Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus. J Transl Med. 2025;23:118. 10.1186/s12967-025-06147-5
- Peng B, Wang W, Gu Q, Wang P, Teng W, et al. Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis. Front Endocrinol (Lausanne). 2024;15:1445878. 10.3389/fendo.2024.1445878
- Wahl L, Samson Chillon T, Seemann P, Ohrndorf S, Ochwadt R, et al. Serum selenium, selenoprotein P and glutathione peroxidase 3 in rheumatoid, psoriatic, juvenile idiopathic arthritis, and osteoarthritis. J Nutr Biochem. 2025;135:109776. 10.1016/j.jnutbio.2024.109776
- Sharabati I, Qafesha RM, Hindawi MD, Amro S, Ayesh BM. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials. Clin Endocrinol (Oxf). 2024;101:669. 10.1111/cen.15128
- Chung CW, Kim K, Park SK, Ju DL, Park YJ, et al. Selenium levels and their association with thyroid autoimmunity and severe preeclampsia in pregnancy: Insights from a prospective ideal breast milk cohort study. Eur Thyroid J. 2024;13. 10.1530/ETJ-24-0007
- Hu C, Yu YF, Tong KK, Hu G, Wu JY, et al. A Mendelian randomization study of the effect of selenium on autoimmune thyroid disease. Eur Rev Med Pharmacol Sci. 2024;28:2988. 10.26355/eurrev_202404_36011
- Khalil DY, Hussein RH, El-Kholy WM. Mesenchymal Stem Cell-Derived Exosomes Loaded with Selenium or Nano Selenium as a Novel Therapeutic Paradigm for Streptozotocin-Induced Type 1 Diabetes in Rats. Biology (Basel). 2024;13. 10.3390/biology13040253
- Potita P, Pruksakorn V, Srichomkwun P, Kingpetch K, Saonanon P. Selenium supplementation in inactive moderate to severe Graves' orbitopathy patients: a randomized controlled trial. Orbit. 2024;43:329. 10.1080/01676830.2024.2315566
- Duntas LH. Reassessing Selenium for the Management of Hashimoto's Thyroiditis: The Selini Shines Bright for Autoimmune Thyroiditis Patients. Thyroid. 2024;34:292. 10.1089/thy.2024.0078
- Wang S, Chen P, He Y, Wei J, Tian L, et al. A follow-up study on factors affecting the recovery of patients with hypothyroidism in different selenium environments. BMC Endocr Disord. 2024;24:14. 10.1186/s12902-024-01536-1
- Huwiler VV, Maissen-Abgottspon S, Stanga Z, Mühlebach S, Trepp R, et al. Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Thyroid. 2024;34:295. 10.1089/thy.2023.0556
- Wang C, Qiao J, Liu S, Piao S, Zhou Y, et al. Selenium in the treatment of mild-to-moderate Graves' orbitopathy: a 5-year prospective controlled cohort study. Endocrine. 2024;84:1072. 10.1007/s12020-023-03672-5
- Yavari M, Akbari M, Ramezani Ahmadi A, Siavash Dastjerdi M, Hashemi MS. Investigating the effect of combined use of selenium and Myo-inositol supplements on thyroid function and autoimmune characteristics in thyroid disorders: a systematic review and meta-analysis. Expert Rev Endocrinol Metab. 2024;19:269. 10.1080/17446651.2023.2295487
- Foos W, Maliakkal Hernandez J, Mansour TN. Selenium supplementation in thyroid eye disease: an updated review from a clinical ophthalmic perspective. Orbit. 2024;43:790. 10.1080/01676830.2023.2276783
- Rezaeimanesh N, Rafiee P, Saeedi R, Khosravian P, Sahraian MA, et al. The effect of crocin-selenium nanoparticles on the cognition and oxidative stress markers of multiple sclerosis patients: a randomized triple-blinded placebo-controlled clinical trial. Biometals. 2024;37:305. 10.1007/s10534-023-00548-z
- Chen X, Yang Y, Chen J, He Y, Huang Y, et al. Dual-driven selenium Janus single-atom nanomotors for autonomous regulating mitochondrial oxygen imbalance to catalytic therapy of rheumatoid arthritis. Redox Biol. 2025;81:103574. 10.1016/j.redox.2025.103574
